INFLUENCE OF ANTERIOR THALAMIC INACTIVATION ON THE RETRIEVAL OF SPATIAL REFERENCE MEMORY AND WORKING MEMORY IN THE RADIAL ARM MAZE

Previous studies have shown that the anterior thalamic nuclei (ATN) contain a large population of head direction cells, which fire as a function of an animal’s directional orientation in an environment, thereby providing a compass-like representation guiding navigation. Recent work has suggested that directional orientation information stemming from the ATN is critical for the generation of hippocampal and parahippocampal spatial representations, and may contribute to the establishment of unique spatial representations in radially oriented tasks such as the radial arm maze. While studies have confirmed that ATN lesions impair the acquisition of new spatial information in variants of the radial maze, few have attempted to dissociate its unique contributions to acquisition vs. retrieval and spatial reference vs working memory in radial tasks. Here, we addressed these questions by training rats in a radial arm maze procedure to asymptotic levels, and after 24hrs, animals were administered muscimol inactivation of the ATN before a 4 trial probe test. We report impairments in retrieval of both spatial reference and working memory, suggesting a general absence of improved navigation across post-inactivation training trials. Taken together, the results above suggest that the ATN modulates the retrieval of previously acquired allocentric spatial information in the radial-arm maze, but also suggests a critical role in the online guidance of accurate spatial behavior. The results are discussed in relation to the thalamo-cortical circuits involved in spatial information processing

Linear Self-Motion Cues Support the Spatial Distribution and Stability of Hippocampal Place Cells

The vestibular system provides a crucial component of place-cell and head-direction cell activity [1-7]. Otolith signals are necessary for head-direction signal stability and associated behavior [8, 9], and the head-direction signal's contribution to parahippocampal spatial representations [10-14] suggests that place cells may also require otolithic information. Here, we demonstrate that self-movement information from the otolith organs is necessary for the development of stable place fields within and across sessions. Place cells in otoconia-deficient tilted mice showed reduced spatial coherence and formed place fields that were located closer to environmental boundaries, relative to those of control mice. These differences reveal an important otolithic contribution to place-cell functioning and provide insight into the cognitive deficits associated with otolith dysfunction

'An Apotheosis of Well-Being': Durkheim on austerity and double-dip recessions

This article is an attempt to contribute a view on the economic crisis from classical sociology, a voice often missing from the sociological response to the crisis. The work of Émile Durkheim provides a unique perspective here centred on morality and inequality produced in a historical context akin to our neoliberal times. It is argued there are four key points to take from Durkheim’s work. Firstly, that the initial credit crunch can be more fully understood with reference to the economic anomie which Durkheim sees as ‘chronic’ in a time of marketization. Secondly, that this creates an antagonistic relationship between a supposedly self-dependent rich and lazy poor. Thirdly, this conception of self-dependency and individual initiative makes any attempt to regulate the economy akin to sacrilege. Finally, the state is unwilling to intervene due to the emergence of ‘pseudo-democracies’. Therefore, Durkheim’s theory accounts for the initial crisis, austerity and double-dip recessions in a sociological framework. The article concludes by returning to the centrality of morality to the crisis for Durkheim and highlighting the omission of this in contemporary debates

Survey of the needs of patients with spinal cord injury: impact and priority for improvement in hand function in tetraplegics\ud

Objective: To investigate the impact of upper extremity deficit in subjects with tetraplegia.\ud \ud Setting: The United Kingdom and The Netherlands.\ud \ud Study design: Survey among the members of the Dutch and UK Spinal Cord Injury (SCI) Associations.\ud \ud Main outcome parameter: Indication of expected improvement in quality of life (QOL) on a 5-point scale in relation to improvement in hand function and seven other SCI-related impairments.\ud \ud Results: In all, 565 subjects with tetraplegia returned the questionnaire (overall response of 42%). Results in the Dutch and the UK group were comparable. A total of 77% of the tetraplegics expected an important or very important improvement in QOL if their hand function improved. This is comparable to their expectations with regard to improvement in bladder and bowel function. All other items were scored lower.\ud \ud Conclusion: This is the first study in which the impact of upper extremity impairment has been assessed in a large sample of tetraplegic subjects and compared to other SCI-related impairments that have a major impact on the life of subjects with SCI. The present study indicates a high impact as well as a high priority for improvement in hand function in tetraplegics.\ud \u

Everyday cosmopolitanism in representations of Europe among young Romanians in Britain

The paper presents an analysis of everyday cosmopolitanism in constructions of Europe among young Romanian nationals living in Britain. Adopting a social representations approach, cosmopolitanism is understood as a cultural symbolic resource that is part of everyday knowledge. Through a discursively-oriented analysis of focus group data, we explore the ways in which notions of cosmopolitanism intersect with images of Europeanness in the accounts of participants. We show that, for our participants, representations of Europe are anchored in an Orientalist schema of West-vs.-East, whereby the West is seen as epitomising European values of modernity and progress, while the East is seen as backward and traditional. Our findings further show that representations of cosmopolitanism reinforce this East/West dichotomy, within a discourse of ‘Occidental cosmopolitanism’. The paper concludes with a critical discussion of the diverse and complex ideological foundations of these constructions of European cosmopolitanism and their implications

Novel designs for minimizing diffraction effects of large segmented mirror telescopes

Diffraction effects of large segmented mirror gaps and secondary mirror support struts produce diffraction peaks or flares that are a detriment to exoplanet detection. In this paper we present a detailed diffraction analysis of innovative segmented mirror concepts utilizing curved segment gaps and secondary support struts that eliminate these diffraction spikes that can obscure the faint exoplanet image. The resulting diffraction performance will be quantitatively compared to that of both monolithic circular pupils and classical hexagonally segmented mirrors. We will utilize performance-based merit functions consisting of both radial and azimuthal profiles of the resulting telescope point spread function

Diffraction analysis of large segmented mirror concepts for exoplanet exploration

Diffraction effects of large segmented mirror gaps and secondary mirror support struts produce diffraction peaks or flares that are a detriment to exoplanet detection. In this paper we present detailed parametric diffraction analyses of an innovative “Pinwheel Pupil” segmented mirror concept utilizing curved segment gaps and secondary support struts that can potentially eliminate these diffraction flares that can obscure a faint exoplanet image. The resulting numerical diffraction performance predictions are quantitatively compared to that of both ideal monolithic circular pupils and classical annular pupils with straight secondary mirror struts. We utilize performance – based merit functions consisting of both radial and azimuthal profiles of the resulting telescope point spread function

Exact sampling from non-attractive distributions using summary states

Propp and Wilson's method of coupling from the past allows one to efficiently generate exact samples from attractive statistical distributions (e.g., the ferromagnetic Ising model). This method may be generalized to non-attractive distributions by the use of summary states, as first described by Huber. Using this method, we present exact samples from a frustrated antiferromagnetic triangular Ising model and the antiferromagnetic q=3 Potts model. We discuss the advantages and limitations of the method of summary states for practical sampling, paying particular attention to the slowing down of the algorithm at low temperature. In particular, we show that such a slowing down can occur in the absence of a physical phase transition.Comment: 5 pages, 6 EPS figures, REVTeX; additional information at http://wol.ra.phy.cam.ac.uk/mackay/exac

A Comparison of Neural Decoding Methods and Population Coding Across Thalamo-Cortical Head Direction Cells

Head direction (HD) cells, which fire action potentials whenever an animal points its head in a particular direction, are thought to subserve the animal’s sense of spatial orientation. HD cells are found prominently in several thalamo-cortical regions including anterior thalamic nuclei, postsubiculum, medial entorhinal cortex, parasubiculum, and the parietal cortex. While a number of methods in neural decoding have been developed to assess the dynamics of spatial signals within thalamo-cortical regions, studies conducting a quantitative comparison of machine learning and statistical model-based decoding methods on HD cell activity are currently lacking. Here, we compare statistical model-based and machine learning approaches by assessing decoding accuracy and evaluate variables that contribute to population coding across thalamo-cortical HD cells